What are B-cells?
B-cells are a variety of white blood cells that produce antibodies. B lymphocytes are immune cells that develop from stem cells in the bone marrow, also referred to as a B-cell.
There are two types of lymphocyte cells in the immune system. They are:
- B-cells or B-lymphocytes
- T-lymphocytes or T-cells are two types of T-cells.
Origination of B-cells
T and B-cells originate initially in the embryo from mesenchymal cells of the yolk sac and then move afterward in the liver and spleen. Lymphocytic stem cells are the progenitor cells. They eventually settle in the marrow of the bones. The process of hematopoiesis causes stem cells to divide and create lymphoblasts, which give rise to immature lymphocytes. Some of them enter the thymus and become thymocytes, which are then prepared for further processes while others undergo preconditioning in the liver during the embryonic stage and in the bone marrow. The cells which were preconditioned in the thymus were named T-cells and the cells which were preconditioned in the liver or bone marrow were named B-cells. Both the cells remain apart from each other. The lifespan of T-cells is 4-5years whereas the B-cells are short-lived with a lifespan of a few days.
How B-cells produce antibodies: Activation Process
A mature B-cell migrates from the bone marrow having membrane-bound immunoglobulin on the surface with a single antigenic specificity. These are naïve cells as they never encountered antigen before, circulate in the blood and lymph and reach the secondary lymphoid organs like the spleen and lymph nodes.
When our body is attacked by foreign particles or antigens, the immunoglobulin receptor which is present on the surface of the B-cells recognizes and specifically binds to the antigens leading to the activation which ultimately starts up the cascade of events like;
- First is the production of short-lived plasmablasts for immediate protection and long-lived plasma cells and memory B-cells for persistent protection via the process of differentiation. This step is also known as the extrafollicular response which takes place outside the lymphoid follicles.
- Further, the plasma cells work via producing antibodies to fight the infection. One type of plasma cell produces only a particular type of antibody and each plasma cell can produce 2000 molecules of an antibody per second or 20 trillion molecules per day.
Mechanism by which activation of B-cells Occurs
There are various mechanisms by which the activation of B-cells takes place and they are:
- T-cell dependent response
- T-cell independent response
The immune response that takes place via the activation of B-cells is called humoral or antibody-mediated immunity and the response that takes place via the activation of T-cells gives rise to cell-mediated immunity.
- T-cell dependent activation: The induction of immune response via the interaction of B-cell with the antigens is known as T-cell-independent activation. This activation occurs when the antigen binds to the specific surface receptor(IgM) present on B-cell. The engulfing of the antigen takes place via endocytosis leading to the presentation of antigenic part on the surface of the B-cell via Major histocompatibility complex proteins which are further recognized by helper T-cells, invigorating the generation of proteins that helps B-cells to proliferate and differentiate to form plasma cells.
- T-cell independent activation: The activation occurs without the direct participation of T cells. The response is much to antigens, in this case, is much stronger as it involves the generation of memory cells, affinity maturation and class switching.
Memory B-cell activation
The activation of the B-cell begins via detecting and binding to the target antigen which was showcased by the parent B-cell while encountering the antigens. As seen earlier, some of the B-cells don’t require T-cells for activation such as virus memory cells but few require the help of T-cells for the activation process to start. The B-cells start the production of plasma cells, which then give rise to huge amounts of soluble antibody.
Functions of B-cells
- B-cells can be activated with the help of antigens as well as T-helper cells.
- Abundance of plasma cells found in the endoplasmic reticulum employed to secrete antibodies.
- Each plasma cell can produce 2000 molecules of an antibody per second or 20 trillion molecules per day.
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Released in 1969, the International D-Series is a series of pickup trucks that were manufactured by American auto manufacturer International Harvester.
The attention on the euro has taken away from the serious problems facing the dollar.
It is a strong and malleable metal and is the perfect one for making wedding bands and rings, as it is highly resistant to wear and tear.
Citizens and military leaders constantly expected Japanese attacks.
Although some British citizens liked to poke fun at the performances, ENSA entertainments were popular with their audiences.
ENSA musicians, actors, comedians, and singers performed in hotels, factories, theaters, and at war-effort work sites.
AGA. “Your Gastroenterologist — A Digestive Specialist.” American Gastroenterological Association.
In December 2015, the 100 Women in Hedge Funds announced the election of the
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They wish to see a couple of years of profitability before they dole out cash.
In the course of the seventeenth and 18th centuries, the Maratha and
Kerala fleets had been expanded, and turned probably the most highly
effective Naval Forces within the subcontinent, defeating European navies
at numerous occasions (See the Battle of Colachel). As well as, Venezuela’s banking sector will
now be capable of participate in foreign money auctions thrice
every week, adding that the government would sell some 2 billion euros amid
a rebound in oil costs. American sanctions.
This has resulted in the Iranian oil bourse buying and selling in a
number of currencies, predominantly the euro for European trade,
and either the yen or euros for gross sales in Asia.
The Maltese scudo itself is pegged to the euro and is barely recognised as authorized tender inside
the Order. Since 2005, stamps issued by the
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currency stays the Maltese scudo. As a public firm, Sexton capital inventory might be issued
to purchase other grocery corporations and fund expansion. Its inside
foreign money, the wŏn, shouldn’t be convertible and thus cannot be used to purchase overseas goods.
A small stream, then called East Brook, ran shut by
the Charles River, about a hundred rods (1,600 toes; 500 metres) from current day Washington Road behind Brookdale Cemetery, and emptied into the Neponset River.
Mom Cabrini High school (MCHS) was a Catholic high school located at 701 Fort Washington Avenue between Fort
Tryon Park and West 190th Road, with a facade on Cabrini Boulevard, in the Hudson Heights neighborhood of Washington Heights in Higher Manhattan, New York City.
Cabrini was the second Catholic college to close in two years in the Washington Heights/Inwood space, after St.
Jude College. In January 2014, the school announced that it might shut at the
tip of the varsity year. On January 8, 1958, a fireplace
broke out on board MS Erling Jarl while the vessel was docked at Bodø.
If you wish to get espresso and mineral stains out of the glass
or stainless steel pot of your coffeemaker, try this variation: Add 1
cup crushed ice, 1 tablespoon water, and 4 teaspoons salt to the pot when it is chilly, swish
round, after which wash as common. Some of the school’s alumni and
mother and father of current students stated they might strive to save the
college, however the Board believed that the deficit
was insurmountable.
The most common capital raising options in Singapore are personal fund, friends and relatives, government funding, angel investing and venture capital financing.
Croatian National Financial institution stated that it had no plans for withdrawing them, and the 1 and a couple of lipa coins were still minted as non-circulating, mainly for numismatic collections.
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For example, most offshore carriers are prohibited to keep up a domestic sales pressure.
Office of the Comptroller of the Currency (thirteen January 2021).
The fact that the moment the IPO is released to the public is the first time that anyone has the ability to purchase the company openly, can certainly give you a fairly good idea about where the stock itself resides when it comes to the value of the offering.
他に、ATS直下地上子を当初位置からさらに16 m手前の位置に移設し、また信号機には番線表示標を設置した。 ※東京メトロ半蔵門線渋谷駅で終了。 Eric S.
Raymond 編、福崎俊博 訳『ハッカーズ大辞典 改定新版』アスキー、2002年、176頁。 Eric S.
Raymond 編、福崎俊博 訳『ハッカーズ大辞典 改定新版』アスキー、2002年、303頁。最終更新
2024年5月30日 (木) 04:58 （日時は個人設定で未設定ならばUTC）。 と、当時のパラサイト・
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